Partners PrEP

Randomized, blinded, placebo-controlled trial to demonstrate if pre-exposure prophylaxis decreases HIV-1 acquisition among HIV-1 uninfected individuals within HIV-1 discordant couples.Couples were followed up to 36 months; the HIV uninfected partner attended monthly visits and the HIV infected partner quarterly visits. All participants received a comprehensive package of HIV prevention services including individual and couples counseling, free condoms, and male circumcision referrals. Participants who seroconverted during follow-up stopped the study drug but continued with follow-up.

Key results: Reduction in HIV infection rate on
1) Daily oral TDF - Women 71%, Men 63%;
2) Daily oral TDF/ FTC - Women 66%, Men 84%

Last updated August 10, 2022