Email Updates

You are here

Home

Impact of Immediate Versus South African Recommendations Guided ART Initiation on HIV Incidence (TasP)

Status
Ongoing
Phase
Open Label
Principal Investigator(s)
François Dabis, Marie-Louise Newell, Deenan Pillay
Objective

This trial is evaluating a public health intervention strategy trial which aims to reduce the incidence of HIV at a population-level.

Prevention Option(s)
Treatment
Study Design
Randomized
Open label
Arms and Assigned Interventions
Description
Drug: Immediate ARV treatment initiation with TDF/FTC/EFV All HIV-infected adults will be offered ART regardless of their immunological and clinical staging. The first line regimen proposed will be Atripla (R), a fixed dose combination containing tenofovir disoproxil (245 mg)/emtricitabine (200 mg)/efavirenz (600 mg)(FTC/TDF/EFV). The dosing will be 1 tablet OD.
Mode of Delivery
Tablet
Products
TDF/FTC (Truvada)
ARMs
Experimental
Description
Other: South African recommendation guided ARV (TDF/FTC/EFV) initiation HIV-infected adult participants will be eligible for ART as per the South African guidelines (August 2011) if: CD4 count ≤ 350 cells/mm3 irrespective of clinical symptoms WHO clinical stage 3 or 4 irrespective of CD4 count MDR or XDR TB The first line regimen proposed will be Atripla (R), a fixes dose combination containing tenofovir disoproxil (245 mg)/emtricitabine (200 mg)/efavirenz (600 mg)(TDF/FTC/EFV). The dosing will be 1 tablet OD.
Mode of Delivery
Tablet
Products
TDF/FTC (Truvada)
ARMs
Experimental
Official Code
Impact of Immediate Versus South African Recommendations Guided ART Initiation on HIV Incidence (TasP)
December 2011
December 2016
Enrollment
22 000
16
Years
Population
Women
Men
Sites

Hlabisa CRS

KwaZulu-Natal
South Africa