The goal of the PrEP Summit: A Skills Building Conference for Frontline Workers was to increase PrEP and PEP awareness and knowledge among frontline HIV prevention workers who serve high-risk populations such as MSM (including young MSM), transgender women, Black and Latino men and women in New York City. PrEP and PEP, in combination with interactive client-centered counseling, can be highly effective tools for HIV prevention. Attendees of the summit increased their understanding of PrEP and PEP use and current research and learned to implement methods to integrate PrEP and PEP information into existing HIV testing and outreach programs.