This HIV Vaccine Awareness Day (HVAD), May 18, 2020, is like no other before. HIV and COVID-19 each present a vivid picture of the need for the vaccine enterprise. A durable, sustainable end to any epidemic depends on a vaccine. HVAD is a day to call attention to the still-urgent need for an HIV vaccine, take stock of progress, recognize the incalculable contributions of trial participants and researchers—and, this year, to explain how work in HIV has created the foundation for the unprecedented speed of COVID-19 vaccine development.