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Px Wire is AVAC's quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. This issue includes updates on what will come next for the AIDS vaccine regimen that showed modest efficacy in the trial known as RV144; the recent VOICE trial modification; progress in demonstration projects, public health guidance and regulatory decision-making around PrEP in the United States; and, a table of early-phase studies of ARV-based prevention strategies for HIV-negative people.