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Px Wire is AVAC's quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. Highlights from this issue include a newly debuted research timeline: “ARV-based Prevention for HIV Negative Adults.” The timeline charts the time-to-approval trajectory, showing efficacy trials, related confirmatory studies and dates of possible regulatory submission for a range of prevention options including oral PrEP with TDF, oral PrEP with TDF/FTC, vaginal and rectal formulations of tenofovir gel and the dapivirine-containing vaginal ring.